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There are several matches for 'NAD-dependent deacetylase'.
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8287 matches
showing page 1 of 415
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organism
protein
1)
Escherichia coli K12
cobB -
Deacetylase
of acs and cheY, chemotaxis regulator;
NAD
-
dependent
lysine
deacetylase
and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Activates the enzyme acetyl-CoA synthetase by deacetylating 'Lys-609' in the inactive, acetylated form of the enzyme. May also modulate the activity of other propionyl-adenosine monophosphate (AMP)-forming enzymes. Belongs to the sirtuin family. Class III subfamily.
[a.k.a. AAC74204.2, b1120, CobB,
NAD-dependent deacetylase
]
2)
Homo sapiens
SIRT6 -
NAD
-
dependent
protein
deacetylase
sirtuin-6;
NAD
-
dependent
protein
deacetylase
. Has
deacetylase
activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. H [...]
[a.k.a. XP_024307307, ENST00000601571.1, ENST00000594279.5]
3)
Homo sapiens
SIRT1 -
NAD
-
dependent
protein
deacetylase
sirtuin-1;
NAD
-
dependent
protein
deacetylase
that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expres [...]
[a.k.a. NM_001314049, CHEMBL4506, 23411]
4)
Homo sapiens
SIRT2 -
NAD
-
dependent
protein
deacetylase
sirtuin-2;
NAD
-
dependent
protein
deacetylase
, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...]
[a.k.a. 5YQN, 5DY5, 3ZGV]
5)
Homo sapiens
SIRT3 -
NAD
-
dependent
protein
deacetylase
sirtuin-3, mitochondrial;
NAD
-
dependent
protein
deacetylase
. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5PO. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription. Acts as a reg [...]
[a.k.a. UPI0001F786DE, CCDS53590.1, XM_011519957]
6)
Homo sapiens
SIRT7 -
NAD
-
dependent
protein
deacetylase
sirtuin-7;
NAD
-
dependent
protein-lysine deacylase that can act both as a
deacetylase
or deacylase (desuccinylase, depropionylase and deglutarylase),
depending
on the context. Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone
deacetylases
, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts a [...]
[a.k.a. ENST00000576156.1, BAA92044.1, SIRT7-208]
7)
Homo sapiens
SIRT4 -
NAD
-
dependent
protein lipoamidase sirtuin-4, mitochondrial; Acts as
NAD
-
dependent
protein lipoamidase, ADP-ribosyl transferase and
deacetylase
. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoch [...]
[a.k.a. ENSP00000202967, HPA029692, NAD+-dependent protein deacetylase sirtuin 4]
8)
Mus musculus
Sirt6 -
NAD
-
dependent
protein
deacetylase
sirtuin-6;
NAD
-
dependent
protein
deacetylase
. Has
deacetylase
activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. On DNA damage, promotes DNA end res [...]
[a.k.a. ENSMUST00000126477.1, ENSMUSG00000034748, R-MMU-5693607]
9)
Mus musculus
Sirt3 -
NAD
-
dependent
protein
deacetylase
sirtuin-3;
NAD
-
dependent
protein
deacetylase
. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5PO. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription. Acts as a regulator of ceram [...]
[a.k.a. NP_071878, R-MMU-9617629, ENSMUST00000137024.7]
10)
Mus musculus
Sirt2 -
NAD
-
dependent
protein
deacetylase
sirtuin-2;
NAD
-
dependent
protein
deacetylase
, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...]
[a.k.a. mmu:64383, Q9EQ18, ENSMUST00000132789]
11)
Mus musculus
Sirt1 -
NAD
-
dependent
protein
deacetylase
sirtuin-1;
NAD
-
dependent
protein
deacetylase
that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (By similarity). Deacetylates a broad range of transcription factors and coregulators, thereby regulating ta [...]
[a.k.a. R-MMU-9617629, AAR23928.1, Q3UNI1]
12)
Mus musculus
Sirt7 -
NAD
-
dependent
protein
deacetylase
sirtuin-7;
NAD
-
dependent
protein-lysine deacylase that can act both as a
deacetylase
or deacylase (desuccinylase, depropionylase and deglutarylase),
depending
on the context. Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac) (By similarity). In contrast to other histone
deacetylases
, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression (By similarity). H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone [...]
[a.k.a. ENSMUSP00000101790, Sirt7-209, AAH26403.1]
13)
Mus musculus
Sirt4 -
NAD
-
dependent
protein lipoamidase sirtuin-4, mitochondrial; Acts as
NAD
-
dependent
protein lipoamidase, ADP-ribosyl transferase and
deacetylase
. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoch [...]
[a.k.a. XM_006530480.2, XM_006530479, NP_598521]
14)
Drosophila melanogaster
Sirt7 -
NAD
-
dependent
protein
deacetylase
Sirt7;
NAD
-
dependent
protein
deacetylase
.
[a.k.a. FBgn0039631, Sirt7-PA, NP_651664.2]
15)
Drosophila melanogaster
Sirt2 -
NAD
-
dependent
protein
deacetylase
Sirt2;
NAD
-
dependent
protein
deacetylase
(By similarity). May be involved in the regulation of life span; Belongs to the sirtuin family. Class I subfamily.
[a.k.a. FBgn0038788, R4HZM7, Regulatory protein SIR2 homolog]
16)
Drosophila melanogaster
Sirt1 -
NAD
-
dependent
histone
deacetylase
sirtuin-1;
NAD
-
dependent
histone
deacetylase
involved in heterochromatic silencing. Mildly suppresses the heterochromatin-mediated silencing phenomenon known as position-effect variegation (PEV). Required for epigenetic silencing of the polycomb group proteins. Has histone H4
deacetylase
activity in vitro. Required maternally for establishing proper segmentation of the embryo. Involved in sex determination. May be involved in the regulation of life span.
[a.k.a. FBgn0024291, Sirt1-PA, FBtr0080434]
17)
Drosophila melanogaster
Sirt6 - Sirtuin 6 (Sirt6) encodes an
NAD
-
dependent
histone
deacetylase
in the class IV of the Sirtuin family. It is involved in chromatin silencing and determination of adult lifespan.
[a.k.a. FBgn0037802, Sirt6-PB, 41254]
18)
Caenorhabditis elegans
sir-2.1 -
NAD
-
dependent
protein
deacetylase
sir-2.1;
NAD
-
dependent
deacetylase
(By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...]
[a.k.a. R11A8.4a, NAD-dependent protein deacetylase sir-2.1, R11A8.4a.1]
19)
Caenorhabditis elegans
sir-2.4 -
NAD
-
dependent
protein
deacetylase
sir-2.4;
NAD
-
dependent
protein
deacetylase
.
[a.k.a. C06A5.11a, NAD-dependent protein deacetylase sir-2.4, C06A5.11a.1]
20)
Saccharomyces cerevisiae
HST1 -
NAD
-
dependent
protein
deacetylase
HST1;
NAD
(+)-
dependent
histone
deacetylase
; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-
dependent
silencing and meiotic repression; non-essential subunit of the Set3C
deacetylase
complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication.
[a.k.a. YOL068C, NP_014573, S000005429]
8287 matches
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